I made a range of changes and hopefully improvements to the PCB. Not only to the layout but also to the schematics. I double checked my wiring and components, replaced the 5US$ Maxim DS1388 real time clock with a cheaper TI BQ32000 for 2US$.
Replaced THT components with SMD and sent it to pcbway.com for quotation. The BOM quotation is absolutely fair priced! The price is comparable to digikey for small numbers. At the moment they run discounts for assembly, for a five prototype PCBs they also only charge 30$ setup costs - dirt cheap!
I gave it a placed the order yesterday - lets wait and see, ETA is 25 days. So if all goes well I will get a nice Christmas present.